Showing posts with label archive material. Show all posts
Showing posts with label archive material. Show all posts

Thursday, 12 February 2015

The Cutting Edge of Mass Spectrometry

Originally written in August 2007...

To dream the impossible dream

One of my good friends asked me the other day when I was going to post another rant on facebook, which made me wonder whether perhaps I have a tendency to start frothing at the mouth rather too often. But it also made me realise that I do have a bit of a something brewing inside, and that for the good of mankind maybe it would be best to let it out before it becomes too toxic...

As quite a few of you know, I work for a small company and we build mass spectrometers. Big ones, small ones, extremely clever ones, and every now and then, ones that try and solve a problem that's never been solved. And that's where I am now - in the early days of a three year R+D project, of the variety that tries to do something that's never been done. Only our customer didn't actually mention that it had never been done when he asked us to attempt it. In fact, up until quite recently, he gave us the distinct impression that he knew what he was talking about.

Our brief is to spend the next 3 years carrying out R+D and eventually building a new instrument to detect very low levels of a variety of interesting compounds. The customer has provided us with a list of 9 'target compounds', with the usual proviso that they'd quite like it if they could detect, well, pretty much anything as it turns out. The 9 on the list are just the the ones they REALLY want to see.

We've been tackling the first stage of this with our usual suck-it-and-see approach, so have simply been running some calibrated standards of the target compounds through our test instrument, just so we know where we're starting from. Our customer helpfully told us "Ooh, you might find that one a bit tricky. We find it very tricky". "Tricky?" we thought. Pah! We eat tricky for breakfast. So we had a go, and, to no-one's great surprise, we saw absolutely nothing. Since in this instance we weren't entirely sure what we were expecting to see, we went trawling through journals, books, papers and (of course) the trusty internet. And we found that the entire scientific community appears completely convinced of the futility of trying to detect this compound using GC-MS (the technique our instrument uses). In fact, we came across entire research groups who were developing new analytical techniques solely because this particular compound can't be detected by GC-MS. At this stage we decided a phone-call to our customer was in order. It went something like this...

Us: You remember that compound that you said we'd find tricky?
Them: Oooh, yes. It's very tricky.
Us: Well, we're struggling to detect it at all, and were wondering what conditions you used, so we can try repeating your results
Them: I've never actually detected it. It's very tricky.
Us: Ah
Them: But I know a man who thinks he might have done, once, but now he's not sure
Us: Hmmm.

So it currently looks as though we'll be spending the next three years trying to do something widely agreed to be impossible. Motivational isn't it?

To fight the unbeatable foe

Meanwhile, we're also applying for funding from the Home Office to have a Clever Idea that will allow us to develop an instrument that will detect all the kinds of things that people who care about Interesting Things might be interested in. (This is the part where I might start frothing).

The Home Office arranged a 'networking' day, where they invited the great, the good, and the slightly confused from british industry and academia to come and be told what the problem was. All these bright sparks could then exchange ideas, form collaborations and generally be fruitful. Experts in interesting statistical analyses could tell hardware bods how to extract the last drop of information from their instrumentation, and all would be splendid. Except the Home Office provided no name badges, no lists of delegates, no lists of companies represented, no information whatsoever about who was there and why. Nor did they provide any time or opportunity for the assembled ranks of British R+D to actually talk to each other. And thus they all went home again, none the wiser, and with no new contacts.

We persevered, made contact with some people we've collaborated with before, discovered, to our surprise, that they'd been at the same event and we'd not seen each other. They have rather more, shall we say, commercial nous than us, and we have considerably more unusual technical ideas than them, so together we put forward a proposal to the HO. This met with approval and we moved through from the first 150-odd proposals to the final 20. At which point we were sent the terms and conditions of the contract the HO would like to hold us to.

Since my boss is like me, only more so, he decided to read all 60-pages of legalese. And buried deep within this, he discovered that the HO would demand, as part of the contract, all of the Intellectual Property Rights of the Clever Idea. Now, we have only once, ever, in the history of the company sold our IPR, and that was for a rather odd contract many years ago that wasn't for a mass spectrometer so we didn't care if we never built another one. We occasionally agree to allow the customer the user rights on the IPR, so if they want to build another one of whatever we've sold them, they can. But we charge a hefty premium for that, and they have to have been heavily involved in the design process. We certainly wouldn't want to sign away rights to a new idea that's right at the heart of our core business.

But it got worse than that. They didn't just want the IPR on the Clever New Bit that they'd have been funding. They wanted 'all background IPR' - so all our designs for every part of a mass spectrometer. The very essence of what we do. The amassed knowledge and expertise of 150 man-years in the mass spectrometry industry. Why? So that they can take the designs and have them made by the cheapest sub-contractor without having to pay us any royalties. Basically our dear government wants to systematically and deliberately destroy innovation in british industry just to make sure they get 'the best deal for the taxpayer'.

We've told them in no uncertain terms that we will not be continuing to tender for this contract unless they change to our re-written terms and conditions. Sometimes you've just got to say "Enough" to the government...

To bear with unbearable sorrow

Update in February 2015: It took us four years, instead of three, but we did manage to build the Miracle Instrument. AND we managed to detect the "quite tricky" compound - the first people ever to do so using GCMS apparently. But we weren't able to publish anything about it, because it was secret. And then there was a financial crash, and a change of government, and the funding was cut, and mass spectrometry suddenly became "unfashionable" for detecting "tricky" compounds. There were newer, shinier, sexier ideas. They didn't work, but that's not the point, they were shiny! With better acronyms! And new! So now, 5 years after being "ahead of the curve" (I quote the government's lead scientist on the subject) and a better analytical tool than anything else available, our instrument is sitting in the corner of a lab gathering dust while newer, shinier, more-excitingly acronymed techniques receive funding, and there still isn't a commercially available instrument to do what we did.

And enterprises of great pith and moment 
With this regard their currents turn awry, 
And lose the name of action.

Purchasing Agents - agents of the devil

Originally written in September 2007...

Purchasing agents are parasites on the face of academia. They're like estate agents only less well-informed, less educated, less useful and probably paid more. They exist solely to prevent researchers being able to do their work. Researchers receive grants to buy equipment to enable them to research. Equipment like mass spectrometers for instance. For the most part (and I admit there are some notable exceptions, but we'll leave them out of it), these researchers are experts in their field. They understand the technical challenges and are the people best placed to specify exactly what the equipment needs to do. We spend months working with them to precisely capture their requirements and design bespoke instrumentation that will satisfy their needs. They, meanwhile, acquire funding to buy their new kit. But are they allowed to spend it? Oh no, they have to ask their purchasing agents to do it for them. Bureaucratic, small-minded, pen-pushing idiots who wouldn't know a mass spectrometer if it landed on them (and I wish it would). People who require certificates to demonstrate that our welding has been carried out in accordance with British Standard blah-de-blah. People who want to know if the electronics is CE marked. People who want copies of invoices from previous customers to prove that we're offering them a fair price. People who don't seem able to grasp that WE HAVEN'T BUILT IT YET! How can we possibly certificate the welding on something that only exists on paper? How can we 'prove' the price of a bespoke piece of engineering to you? And no, you can't have a discount either. I don't care if you're a university. The price is the price.

One of the many government labs in this country has been trying to buy a large instrument from us since the end of last year, and the current news is that the contract will be delayed until NEXT year. It's already been through a budget-approval board, a board to assess the validity of the experiment to be done (both entirely reasonable), a health and safety review board, a national security review, and an installation review. Now it turns out that it needs to have a panel of purchasing agents involved. Not just one, but several. The money is approved by everyone from God downwards and the researcher is champing at the bit trying to do some more work, but no, some scientifically-illiterate wonk gets to decide when or if we get the contract. Never mind the fact that we're the only people in the world that will make one of these instruments. Never mind the fact that some of the country's top scientists have to sit twiddling their thumbs, unable to make progress for OVER A YEAR simply because they're not considered trustworthy enough to buy their own instrumentation. Let them be responsible for our nuclear deterrent, but for goodness sake don't let them buy a voltmeter!

Once again HM Government does its best to crush British engineering, ingenuity and enterprise under the heel of bureaucracy...

Update February 2015:
They never did order the instrument. They had one of those eensy-weensy accidents that you don't really want to have if you run a nuclear laboratory and the funds were all diverted to making sure it didn't turn into a "holy shit, what have we done?" kind of accident. So maybe it was a good thing they didn't spend their money on a new instrument. But purchasing agents are still a waste of oxygen.

2014 Reading List

I've never kept any kind of record of what I read, or when I've read it, and last year I was interested to see the distribution of my reading, both in my choice of reading matter, and how many books I read in total. The only effect that making the list as I went along had was that I made a little bit of a conscious effort NOT to read lots of books by the same author back to back. Though, to be honest in May and June I went a bit mad on Eric Ambler, Ed McBain, Gavin Lyall and Michael Dibdin, but you can't have everything. The one thing this list doesn't do is give any kind of indication of how much I enjoyed the books, what I thought of them, or whether I'd recommend them to anyone else. So perhaps this year's list will include some thoughts after each book!

January

Beyond Black - Hilary Mantel
Speaking from among the Bones - Alan Bradley
Standing in another man's grave -  Ian Rankin
Espedair Street - Ian Banks
The 44 Vintage - Anthony Price
Carrying the Fire - Michael Collins

February

Complicity - Iain Banks
The Red Thumb Mark - R Austin Freeman
Northanger Abbey - Jane Austen
Full Dark House - Christopher Fowler

March

Wolf Hall - Hilary Mantel
The Secret Pilgrim -John le Carre

April

Where The Bodies are Buried - Christopher Brookmyre
Tomorrow's ghost - Anthony Price
The Stranger House - Reginald Hill
The Secret Servant -  Gavin Lyall
Bring up the Bodies - Hilary Mantel

May

The conduct of Major Maxim - Gavin Lyall
The Crocus List - Gavin Lyall
Uncle Target - Gavin Lyall
Old Filth - Jane Gardam
Fever Pitch - Nick Hornby
Cosi fan Tutti - Michael Dibdin
The Rivers of London - Ben Aaronovitch
A Long Finish - Michael Dibdin
The Heckler - Ed McBain

June

Cop Hater - Ed McBain
Shooting Script - Gavin Lyall
Epitaph for a Spy - Eric Ambler
Journey into Fear - Eric Ambler
Lady, Lady I did it! - Ed McBain
Blood Rain - Michael Dibdin
Crucible of Gold - Naomi Novik

July

Moon over Soho - Ben Aaronovitch
The Man in the Wooden Hat - Jane Gardam
The Last Runaway - Tracy Chevalier
Stalky and Co - Rudyard Kipling
The Most Dangerous Game - Gavin Lyall

August

The Adventures of Tom Sawyer - Mark Twain
The Scarlet Pimpernel - Baroness Orczy
The Catcher in the Rye - J D Salinger
The Elusive Pimpernel - Baroness Orczy
Enigma - Robert Harris
Eldorado - Baroness Orczy

September

And then you die - Michael Dibdin
If this is a man - Primo Levi
We are all completely beside ourselves - Karen Joy Fowler
Police at the Funeral - Margery Allingham

October

Lord Tony's Wife - Baroness Orczy
The Moro Affair - Leonardo Sciascia
Hide your Eyes - Margery Allingham
Miss Garnet's Angel - Salley Vickers
The War of the Worlds - HG Wells

November

Last Friends - Jane Gardam
Living Dolls - Natasha Walker
The Triumph of the Scarlet Pimpernel - Baroness Orczy
Towards the End of the Morning - Michael Frayn
Kolymsky Heights - Lionel Davidson

December

The Wake - Paul Kingsnorth
Saints of the Shadow Bible - Ian Rankin
A Delicate Truth - John le Carre
The Flight of the Maidens - Jane Gardam